Looking for younger, healthier skin without surgery?
Polynucleotides for skin rejuvenation are rapidly becoming one of the most effective aesthetic treatments available today. Created from unique DNA fragments, polynucleotide skin injections work from the inside out to repair hydration and revitalize your skin.
Let’s face it.
There’s a serious lack of knowledge when it comes to polynucleotides. With the aesthetic medicine industry growing to a market cap of over $89 billion worldwide, patients are demanding natural and minimally invasive treatment options.
Polynucleotides are stepping up to meet that demand.
A polynucleotide aesthetic treatment could be one of the best decisions you make for your skin. These revolutionary injectables help your body rejuvenate itself to produce long-lasting and natural-looking results.
Read on to learn everything you need to know about polynucleotides.
Table of Contents
What Are Polynucleotides?
Polynucleotides are synthesized fragments of DNA harvested from natural sources around the world. Unlike synthetically produced compounds, polynucleotides are biocompatible. This means they get absorbed by the body without negative reaction.
Due to their structure, polynucleotides act as biostimulators when injected into the skin. The tissues in your skin read these molecules as damaged skin cells. Your skin responds by activating natural healing responses to repair the problem.
Basically…
Polynucleotides trigger collagen and elastin production inside your skin. Collagen and elastin are responsible for your skin’s firmness, tightness, and overall youthfulness. As the body ages, it produces less of these all-important proteins.
Polynucleotide treatment turns that process right back on.
Why Polynucleotides Work So Well For Skin
Now that the basics are covered, let’s take a deeper look at why polynucleotides are so beneficial.
For starters, aesthetic physicians love polynucleotides because they work at a cellular level. Most treatments focus on masking aging skin. Polynucleotides target the underlying causes of wrinkles and skin laxity.
They boost collagen production by triggering fibroblasts. Fibroblasts are cells within the skin that produce collagen and elastin.
When more collagen and elastin are produced, the skin becomes firmer and tighter. Repeated treatments compound that effect by continuing to stimulate fibroblast activity.
The evidence is clear too. Researchers in a comprehensive study published in the Journal of Cosmetic Dermatology concluded:
Polynucleotide injections showed beneficial results with respect to the improvement of wrinkles, texture, and elasticity in all included studies.
This wasn’t limited to surface level improvements either.
When used alone or as part of a cumulative treatment strategy, polynucleotides help decrease inflammation, attract and hold water molecules for deep hydration, and strengthen skin cell structures.
The Top Benefits Of Polynucleotides For Skin
Here are the five biggest benefits of polynucleotides for your skin. The beauty of each of these benefits has been scientifically documented as well as proven out in clinical settings.
Increases Collagen Production
Ah yes, collagen. Collagen is responsible for giving your skin that youthful appearance. As you age, collagen production slows down which causes skin to sag and wrinkle.
Not only do polynucleotide treatments promote collagen production, but they can increase collagen levels by up to 47% in just 23 days.
Hydrates Skin From Within
Want plump, dewy skin? Polynucleotides fit magnetic water molecules that help skin retain moisture from the inside out.
Patients who underwent polynucleotide treatment saw significant improvements in skin hydration during clinical trials.
Reduction Of Fine Lines And Wrinkles
Couple increased collagen production with elastin, and you’ve got a recipe for smoother skin. Polynucleotides help improve the appearance of fine lines and wrinkles by restoring skin quality.
They don’t simply mask wrinkles like other injectable treatments.
Smoother Skin Texture And Tone
Do you sometimes notice your skin looks dull or uneven? Polynucleotides help skin return to its natural state by improving cellular function.
Clinical studies have shown improvements in skin texture, evenness, and firmness after multiple treatments.
Minimal Downtime
Polynucleotide injections don’t require any downtime. Sure, you might be left with some mild swelling and redness for 24-48 hours post treatment. But that’s about it.
Patients can walk out the door and return to normal activity immediately after their appointment.
Polynucleotides for skin recovery are nothing short of amazing. Here’s an aesthetic treatment that improves skin from the inside out with scientific backing, real-world clinical data, and fast-acting results.
How Polynucleotides Compare To Other Treatments
Believe it or not, polynucleotides are not trying to replace other aesthetic treatments. When used correctly, polynucleotides can enhance almost any other treatment you choose to undergo.
Polynucleotides restore skin to its natural state.
- Think about dermal fillers. They insert collagen into your skin to add volume. Over time, these fillers will break down. Your skin doesn’t become any tighter or smoother just because you got fillers.
- Botox doesn’t actually help your skin look or feel better. In fact, it paralyzes facial muscles to reduce the appearance of wrinkles.
- Hyaluronic acid plumping treatments help with hydration and volume, but they don’t stimulate collagen production.
It’s becoming more common to see skin professionals recommend polynucleotides before and after other aesthetic treatments. They improve the baseline health of your skin so that other treatments have the best environment to work with.
You may still want to treat yourself with other rejuvenating therapies. Polynucleotides are not a magical cure-all, but they do help repair the skin itself.
What You Should Expect From Treatment
Ready to book your first polynucleotide skin treatment? Here’s what you should know before you go.
Treatment courses will usually consist of three treatments spaced about 2-3 weeks apart. Most doctors will apply a numbing cream to your skin prior to getting your injections.
And here’s the caveat…
Polynucleotide results will not happen overnight. Remember these work by boosting your skin’s natural recovery processes. You should notice improvements to hydration and texture within 2-4 weeks.
It can take up to 8-12 weeks to see things like collagen production kick into high gear.
As with any aesthetic treatment, maintenance sessions will be required to prolong your results. Polynucleotide injections are typically repeated once every 6-12 months.
The Bottom Line
Needless to say, polynucleotide treatments are an incredible addition to the aesthetic industry. Not only can polynucleotides improve the appearance and texture of your skin, but the science behind the treatment has been proven effective time and time again.
Polynucleotides help your skin:
- Recover from within
- Increase collagen and elastin production
- Improve your skin’s appearance and texture
- Have little to no downtime
If you’re serious about getting your skin looking its best, don’t sleep on polynucleotides.

